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A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer.


ABSTRACT: The aim of this study was to directly compare the prognostic value of cumulative scores and composite ratios in patients with operable rectal cancer. Within a single surgical unit preoperative differential blood cell results including neutrophil (N), lymphocyte (L), monocyte (M) and platelet (P) counts, as well as CRP (C) and albumin (A) levels were recorded. These results were used to construct a series of composite ratios (NLR, PLR, LMR, CAR) and cumulative scores (NLS, PLS, LMS, NPS, mGPS). The relationship between composite ratios and the cumulative scores and clinicopathological characteristics, cancer specific survival (CSS) and overall survival (OS) were examined. A total of 413 patients were included. When adjusted for TNM stage, surgical approach, time of surgery and margin involvement mGPS (p?< 0.05) was associated with CSS. In addition, most composite ratios/scores showed correlations with neoadjuvant therapy (p?

SUBMITTER: Dolan RD 

PROVIDER: S-EPMC7578034 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer.

Dolan Ross D RD   Alwahid Muhammed M   McSorley Stephen T ST   Park James H JH   Stevenson Richard P RP   Roxburgh Campbell S CS   Horgan Paul G PG   McMillan Donald C DC  

Scientific reports 20201021 1


The aim of this study was to directly compare the prognostic value of cumulative scores and composite ratios in patients with operable rectal cancer. Within a single surgical unit preoperative differential blood cell results including neutrophil (N), lymphocyte (L), monocyte (M) and platelet (P) counts, as well as CRP (C) and albumin (A) levels were recorded. These results were used to construct a series of composite ratios (NLR, PLR, LMR, CAR) and cumulative scores (NLS, PLS, LMS, NPS, mGPS). T  ...[more]

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