Ontology highlight
ABSTRACT:
SUBMITTER: Crouse B
PROVIDER: S-EPMC7578047 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Crouse Bethany B Robinson Christine C Huseby Kelcher April A Laudenbach Megan M Abrahante Juan E JE Pravetoni Marco M
NPJ vaccines 20201021
Opioid use disorders (OUD) affect over 27 million people worldwide. Anti-opioid vaccines offer a promising strategy to treat OUD and prevent overdose. Using immunomodulation of cytokine signaling to increase vaccine efficacy, this study found that blocking IL-4 improved the efficacy of vaccines targeting oxycodone and fentanyl in male and female mice. Genetic deletion of the IL-4 receptor, STAT6, or antibody-based depletion of IL-13, did not increase vaccine efficacy against opioids, suggesting ...[more]