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The Impact of HMGB1 Polymorphisms on Prostate Cancer Progression and Clinicopathological Characteristics.


ABSTRACT: Prostate cancer is one of the major cancers of the genitourinary tract. High-mobility group box 1 (HMGB1) was suggested as a promising therapeutic target for prostate cancer. In this study, we aim to elucidate the associations of HMGB1 single nucleotide polymorphisms (SNPs) with prostate cancer susceptibility and clinicopathological characteristics. The HMGB1 SNPs rs1412125, rs2249825, rs1045411, and rs1360485 in 579 prostate cancer patients and 579 cancer-free controls were analyzed with real-time polymerase chain reactions (real-time PCR). All of the data were evaluated with SAS statistical software. Our results showed that the HMGB1 rs1045411 T allele genotype was significantly associated with advanced pathologic T stage (odds ratio (OR) = 1.433, 95% confidence interval (CI) = 1.021?2.012; p = 0.037) and pathologic N1 stage (OR = 2.091, 95% CI = 1.160?3.767; p = 0.012), and the rs1360485 polymorphic CT + TT genotype was associated with pathologic Gleason grade group (4 + 5) (OR = 1.583, 95% CI = 1.017?2.462; p = 0.041), pathologic T stage (3 + 4) (OR = 1.482, 95% CI = 1.061?2.070; p = 0.021), and pathologic N1 stage (OR = 2.131, 95% CI = 1.178?3.852; p = 0.011) compared with their wild-type carriers. In conclusion, our results revealed that the HMGB1 SNPs were associated with the clinical status of prostate cancer. The HMGB1 SNPs may have the potential to predict prostate cancer disease progression.

SUBMITTER: Chou YE 

PROVIDER: S-EPMC7579148 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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The Impact of <i>HMGB1</i> Polymorphisms on Prostate Cancer Progression and Clinicopathological Characteristics.

Chou Ying-Erh YE   Yang Po-Jen PJ   Lin Chia-Yen CY   Chen Yen-Yu YY   Chiang Whei-Ling WL   Lin Pei-Xuan PX   Huang Zih-Yun ZY   Huang Matthew M   Ho Yung-Chuan YC   Yang Shun-Fa SF  

International journal of environmental research and public health 20201003 19


Prostate cancer is one of the major cancers of the genitourinary tract. High-mobility group box 1 (HMGB1) was suggested as a promising therapeutic target for prostate cancer. In this study, we aim to elucidate the associations of <i>HMGB1</i> single nucleotide polymorphisms (SNPs) with prostate cancer susceptibility and clinicopathological characteristics. The <i>HMGB1</i> SNPs rs1412125, rs2249825, rs1045411, and rs1360485 in 579 prostate cancer patients and 579 cancer-free controls were analyz  ...[more]

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