Spur Cells Causing Severe and Transfusion-Refractory Anemia in Patients With Acute-on-Chronic Liver Failure.
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ABSTRACT:
SUBMITTER: Kedarisetty CK
PROVIDER: S-EPMC7579423 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Spur Cells Causing Severe and Transfusion-Refractory Anemia in Patients With Acute-on-Chronic Liver Failure.
Kedarisetty Chandan Kumar CK Kumar Ramesh R
Cureus 20200921 9
Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of chronic liver disease associated with organ failures. Anemia of diverse etiology is common in patients with ACLF. Spur cell anemia (SCA) is a form of acquired hemolytic anemia that occurs rarely in such patients due to dysregulated lipids metabolism. Spur cells are large erythrocytes with spike-like projections, which predispose them for sequestration and destruction in splenic canaliculi. There is a paucity of dat ...[more]
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