Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC7579710 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Wu Xinbo X Yu Haiyang H Zhou Haichao H Li Zihua Z Huang Hui H Xiao Fajiao F Xu Shaochen S Yang Yunfeng Y
Journal of cellular and molecular medicine 20200910 20
Osteosarcoma (OS) is the most common primary malignant bone tumour in children and adolescents. The long-term survival rate of OS patients is stubbornly low mainly due to the chemotherapy resistance. We therefore aimed to investigate the antitumoral effects and underlying mechanisms of proanthocyanidin B2 (PB2) on OS cells in the current study. The effect of PB2 on the proliferation and apoptosis of OS cell lines was assessed by CCK-8, colony formation, and flow cytometry assays. The target gene ...[more]