Ontology highlight
ABSTRACT:
SUBMITTER: Hu M
PROVIDER: S-EPMC7580382 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Hu Ming M Cherkaoui Ines I Misra Shivani S Rutter Guy A GA
Frontiers in endocrinology 20201008
The inheritance of variants that lead to coding changes in, or the mis-expression of, genes critical to pancreatic beta cell function can lead to alterations in insulin secretion and increase the risk of both type 1 and type 2 diabetes. Recently developed clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) gene editing tools provide a powerful means of understanding the impact of identified variants on cell function, growth, and survival and might ultimately provide a means, ...[more]