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Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents.

ABSTRACT: The triazole ring system has emerged as an exciting prospect in the optimization studies of promising lead molecules in the quest for new drugs for clinical usage. Several marketed drugs possess these versatile moieties that are used in a wide range of medical indications. This stems from the unique intrinsic properties of triazoles, which impart stability to the basic pharmacophoric unit with an added advantage of being a bioisostere of different chemical functionalities. In the last decade, the use of triazoles as bioisosteres and linkers in the development of microtubule targeting agents has been extensively investigated. The present review highlights the advances in this promising area of drug discovery and development.

SUBMITTER: Malik MS

PROVIDER: S-EPMC7580775 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents.

Malik M Shaheer MS Ahmed Saleh A SA Althagafi Ismail I II Ansari Mohammed Azam MA Kamal Ahmed A

RSC medicinal chemistry 20200129 3

The triazole ring system has emerged as an exciting prospect in the optimization studies of promising lead molecules in the quest for new drugs for clinical usage. Several marketed drugs possess these versatile moieties that are used in a wide range of medical indications. This stems from the unique intrinsic properties of triazoles, which impart stability to the basic pharmacophoric unit with an added advantage of being a bioisostere of different chemical functionalities. In the last decade, th ...[more]

PMID: 33479639

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