Self-amplifying RNA vaccines for infectious diseases.
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ABSTRACT:
SUBMITTER: Bloom K
PROVIDER: S-EPMC7580817 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Self-amplifying RNA vaccines for infectious diseases.
Bloom Kristie K van den Berg Fiona F Arbuthnot Patrick P
Gene therapy 20201022 3-4
Vaccinology is shifting toward synthetic RNA platforms which allow for rapid, scalable, and cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development pipeline is based on in vitro transcription of antigen-encoding sequences or immunotherapies as synthetic RNA transcripts, which are then formulated for delivery. This approach may enable a quicker response to emerging disease outbreaks, as is evident from the swift pursuit of RNA vaccine candidates for the global SAR ...[more]
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