Improved penicillin susceptibility of Streptococcus pneumoniae and increased penicillin consumption in Japan, 2013-18.

ABSTRACT:

Objectives

To examine the association between penicillin susceptibility of Streptococcus pneumoniae and penicillin consumption in Japan.

Methods

We used Japan Nosocomial Infection Surveillance data on the susceptibility of S. pneumoniae and sales data obtained from IQVIA Services Japan K.K. for penicillin consumption. We analysed both sets of data by decomposing them into seasonality and chronological trend components. The cross-correlation function was checked using Spearman's rank correlation coefficient to examine the correlation between susceptibility and consumption.

Results

After adjusting for seasonality, the susceptibility of S. pneumoniae to penicillins gradually improved (55.7% in 2013 and 60.6% in 2018, respectively) and penicillin consumption increased dur

SUBMITTER: Tsuzuki S 

PROVIDER: S-EPMC7580930 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature