Ontology highlight
ABSTRACT:
SUBMITTER: Helble JD
PROVIDER: S-EPMC7580951 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Helble Jennifer D JD Mann Alexander O AO Starnbach Michael N MN
PloS one 20201022 10
Memory antigen-specific CD4+ T cells against Chlamydia trachomatis are necessary for protection against secondary genital tract infection. While it is known that naïve antigen-specific CD4+ T cells can traffic to the genital tract in an antigen-specific manner, these T cells are not protective during primary infection. Here, we sought to compare the differences between memory and naïve antigen-specific CD4+ T cells in the same mouse following secondary infection using transgenic CD4+ T cells (NR ...[more]