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Magnetic Resonance Imaging for Evaluation of Interstitial Fibrosis in Kidney Allografts.


ABSTRACT: Interstitial fibrosis (IF) is the common pathway of chronic kidney injury in various conditions. Magnetic resonance imaging (MRI) may be a promising tool for the noninvasive assessment of IF in renal allografts. Methods:This prospective trial was primarily designed to investigate whether the results of T1-weighted MRI associate with the degree of IF. Thirty-two kidney transplant recipients were subjected to 1.5-Tesla MRI scans shortly before or after routine allograft biopsies. MRI parameters [T1 and T2 relaxation times; apparent diffusion coefficient (ADC)] were assessed for cortical and medullary sections. Results:Advanced IF (Banff ci score >1) was associated with higher cortical T1 (but not T2) values [1451 (median; interquartile range: 1331-1506) versus 1306 (1197-1321) ms in subjects with ci scores ?1; P = 0.011; receiver operating characteristic area under the curve for prediction of ci > 1: 0.76]. In parallel, T1 values were associated with kidney function and proteinuria. There was also a relationship between IF and corticomedullary differences on ADC maps (receiver operating characteristic area under the curve for prediction of ci ? 1: 0.79). Conclusions:Our results support the use of MRI for noninvasive assessment of allograft scarring. Future studies will have to clarify the role of T1 (and ADC) mapping as a surrogate endpoint reflecting the progression of chronic graft damage.

SUBMITTER: Beck-Tolly A 

PROVIDER: S-EPMC7581173 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Magnetic Resonance Imaging for Evaluation of Interstitial Fibrosis in Kidney Allografts.

Beck-Tölly Andrea A   Eder Michael M   Beitzke Dietrich D   Eskandary Farsad F   Agibetov Asan A   Lampichler Katharina K   Hamböck Martina M   Regele Heinz H   Kläger Johannes J   Nackenhorst Maja M   Böhmig Georg A GA  

Transplantation direct 20200715 8


Interstitial fibrosis (IF) is the common pathway of chronic kidney injury in various conditions. Magnetic resonance imaging (MRI) may be a promising tool for the noninvasive assessment of IF in renal allografts.<h4>Methods</h4>This prospective trial was primarily designed to investigate whether the results of T1-weighted MRI associate with the degree of IF. Thirty-two kidney transplant recipients were subjected to 1.5-Tesla MRI scans shortly before or after routine allograft biopsies. MRI parame  ...[more]

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