Ontology highlight
ABSTRACT:
SUBMITTER: Abdel-Bar HM
PROVIDER: S-EPMC7581272 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Abdel-Bar Hend Mohamed HM Khater Shaymaa Elsayed SE Ghorab Dalia Mahmoud DM Al-Mahallawi Abdulaziz Mohsen AM
ACS omega 20201006 41
The aim of this study was to investigate the feasibility of hexosomes (HEXs) as competent platforms for fluoxetine hydrochloride (FH) repurposing against HepG2 hepatocellular carcinoma. Different FH-loaded HEX formulations were prepared and optimized by the hot emulsification method. The HEX features such as particle size, ζ potential, and drug entrapment efficiency (EE%) can be tailored by tuning HEX components and fabrication conditions. The composition of the optimized FH hexosome (OFH-HEX) w ...[more]