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Introducing polymer conductance in diagnostically relevant transduction.

ABSTRACT: In this work we demonstrate that an impedance derived capacitance method is able to cleanly resolve the resonant conductance characteristics of an electrode-confined polymer film. In decorating the film with receptors, this conductance is thereafter modulated by the capturing of specific targets, demonstrated herein with C-reactive protein. This entirely reagentless and single step marker quantification is relevant to the drive of moving assays to a scaleable format requiring minimal user intervention.

SUBMITTER: Baradoke A

PROVIDER: S-EPMC7581358 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Introducing polymer conductance in diagnostically relevant transduction.

Baradoke Ausra A Santos Adriano A Bueno Paulo R PR Davis Jason J JJ

Biosensors & bioelectronics 20201022

In this work we demonstrate that an impedance derived capacitance method is able to cleanly resolve the resonant conductance characteristics of an electrode-confined polymer film. In decorating the film with receptors, this conductance is thereafter modulated by the capturing of specific targets, demonstrated herein with C-reactive protein. This entirely reagentless and single step marker quantification is relevant to the drive of moving assays to a scaleable format requiring minimal user interv ...[more]

PMID: 33166803

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