Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline.

ABSTRACT:

Objective

The goal of this study was to examine sex differences in tau distribution across the brain of older adults, using positron emission tomography (PET), and investigate how these differences might associate with cognitive trajectories.

Methods

Participants were 343 clinically normal individuals (women, 58%; 73.8 [8.5] years) and 55 individuals with mild cognitive impairment (MCI; women, 38%; 76.9 [7.3] years) from the Harvard Aging Brain Study and the Alzheimer's Disease Neuroimaging Initiative. We examined ¹⁸ F-Flortaucipir (FTP)-positron emission tomography (PET) signal across 41 cortical and subcortical regions of interest (ROIs). Linear regression models estimated the effect of sex on FTP-signal for each ROI after adjusting for age and cohort. We also e

SUBMITTER: Buckley RF 

PROVIDER: S-EPMC7581543 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature