Ontology highlight
ABSTRACT:
SUBMITTER: Tian T
PROVIDER: S-EPMC7582157 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Tian Tao T Guo Tongqi T Zhen Wei W Zou Jianjun J Li Fuyong F
Cell death & disease 20201022 10
Based on their histological appearance, gliomas are a very common primary tumor type of the brain and are classified into grades, Grade I to Grade IV, of the World Health Organization. Treatment failure is due to the cancer stem cells (CSC) phenotype maintenance and self-renewal. BET degraders such as ZBC260 represents a novel class of BET inhibitors that act by inducing BET proteins degradation. This study explores the mode of action and effects of ZBC260 in vivo and in vitro against glioma. By ...[more]