Ontology highlight
ABSTRACT:
SUBMITTER: Noberini R
PROVIDER: S-EPMC7582528 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Noberini Roberta R Morales Torres Cristina C Savoia Evelyn Oliva EO Brandini Stefania S Jodice Maria Giovanna MG Bertalot Giovanni G Bonizzi Giuseppina G Capra Maria M Diaferia Giuseppe G Scaffidi Paola P Bonaldi Tiziana T
International journal of molecular sciences 20201004 19
Epigenetic aberrations have been recognized as important contributors to cancer onset and development, and increasing evidence suggests that linker histone H1 variants may serve as biomarkers useful for patient stratification, as well as play an important role as drivers in cancer. Although traditionally histone H1 levels have been studied using antibody-based methods and RNA expression, these approaches suffer from limitations. Mass spectrometry (MS)-based proteomics represents the ideal tool t ...[more]