Ontology highlight
ABSTRACT:
SUBMITTER: Imperatore C
PROVIDER: S-EPMC7582650 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Imperatore Concetta C Varriale Antonio A Rivieccio Elisa E Pennacchio Angela A Staiano Maria M D'Auria Sabato S Casertano Marcello M Altucci Carlo C Valadan Mohammadhassan M Singh Manjot M Menna Marialuisa M Varra Michela M
International journal of molecular sciences 20200926 19
The synthesis of two 5'-end (4-dimethylamino)azobenzene conjugated G-quadruplex forming aptamers, the thrombin binding aptamer (TBA) and the HIV-1 integrase aptamer (T30695), was performed. Their structural behavior was investigated by means of UV, CD, fluorescence spectroscopy, and gel electrophoresis techniques in K<sup>+</sup>-containing buffers and water-ethanol blends. Particularly, we observed that the presence of the 5'-(4-dimethylamino)azobenzene moiety leads TBA to form multimers instea ...[more]