Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury.
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ABSTRACT:
SUBMITTER: Minta K
PROVIDER: S-EPMC7582923 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury.
Minta Karolina K Brinkmalm Gunnar G Al Nimer Faiez F Thelin Eric P EP Piehl Fredrik F Tullberg Mats M Jeppsson Anna A Portelius Erik E Zetterberg Henrik H Blennow Kaj K Andreasson Ulf U
Scientific reports 20201022 1
Matrix metalloproteinases (MMPs) are extracellular enzymes involved in the degradation of extracellular matrix (ECM) proteins. Increased expression of MMPs have been described in traumatic brain injury (TBI) and may contribute to additional tissue injury and blood-brain barrier damage. The objectives of this study were to determine longitudinal changes in cerebrospinal fluid (CSF) concentrations of MMPs after acute TBI and in relation to clinical outcomes, with patients with idiopathic normal pr ...[more]
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