Ontology highlight
ABSTRACT:
SUBMITTER: Bryk M
PROVIDER: S-EPMC7582975 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Bryk Marta M Chwastek Jakub J Kostrzewa Magdalena M Mlost Jakub J Pędracka Aleksandra A Starowicz Katarzyna K
International journal of molecular sciences 20201006 19
Osteoarthritis (OA) is a degenerative joint disease manifested by movement limitations and chronic pain. Endocannabinoid system (ECS) may modulate nociception via cannabinoid and TRPV1 receptors. The purpose of our study was to examine alterations in the spinal and joint endocannabinoid system during pain development in an animal model of OA. Wistar rats received intra-articular injection of 3mg of sodium monoiodoacetate (MIA) into the knee joint. Animals were sacrificed on day 2, 7, 14, 21, 28 ...[more]