Serum IgE in the clinical features and disease outcomes of IgG4-related disease: a large retrospective cohort study.

ABSTRACT: OBJECTIVE:The aim of this study was to investigate the role of serum IgE levels in the clinical features and outcomes of IgG4-related disease (IgG4-RD). METHODS:We retrospectively enrolled 459 newly diagnosed IgG4-RD patients with serum IgE examined at baseline from 2012 to 2019 and compared the clinical features between group A (serum IgE level???60 KU/L) and group B (serum IgE level?>?60 KU/L). Subsequently, 312 patients who had been followed up for ??1?year were further selected to evaluate the correlation between serum IgE level and disease outcome. RESULTS:At baseline, the serum IgE level was positively correlated with the serum IgG4 level (r?=?0.1779, P?=?0.0001), eosinophil count (r?=?0.3004, P??125 KU/L at baseline was a risk factor for disease relapse (hazard ratio [HR], 1.894 [95% confidence interval (CI) 1.022-3.508]; P?=?0.042). Cox regression analysis showed that elevation of the eosinophil count was a risk factor for relapse in both group A and group B patients (HR, 8.504 [95% CI 1.071-42.511]; P?=?0.009; and HR, 2.078 [95% CI 1.277-3.380]; P?=?0.003, respectively), and the involvement of the lacrimal gland (HR, 1.756 [95% CI 1.108-2.782]; P?=?0.017), submandibular gland (HR, 1.654 [95% CI 1.037-2.639]; P?=?0.035), and kidney (HR, 3.413 [95% CI 1.076-10.831]; P?=?0.037) were also risk factors for relapse in group B patients. CONCLUSION:IgG4-RD patients with high serum IgE levels at baseline were more likely to have higher disease activity, and baseline high IgE levels were associated with disease relapse.

SUBMITTER: Zhou J 

PROVIDER: S-EPMC7583198 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature