Impact of frailty on health-related quality of life 1 year after transcatheter aortic valve implantation.

ABSTRACT: BACKGROUND:Transcatheter aortic valve implantation (TAVI) brings symptom relief and improvement in health-related quality of life (HRQoL) in the majority of patients treated for symptomatic, severe aortic stenosis. However, there is a substantial group of patients that do not benefit from TAVI. The aim of this study is to investigate the impact of frailty on HRQoL 1 year after TAVI. METHODS:The TAVI Care & Cure Program is an ongoing, prospective, observational study including patients referred for TAVI to our institution. A comprehensive geriatric assessment was performed to evaluate existence of frailty using the Erasmus Frailty Score (EFS). HRQoL was assessed using the EQ-5D-5 L at baseline and 1 year after TAVI. RESULTS:239 patients underwent TAVI and completed HRQoL assessment 1 year after TAVI. Seventy (29.3%) patients were classified as frail (EFS???3). In non-frail patients, the EQ-5D-5 L index did not change (0.71(± 0.22) to 0.68(± 0.33) points, P =?0.22); in frail patients, the EQ-5D-5 L index decreased from 0.55(±0.26) to 0.44 points (±0.33) (P =?0.022). Frailty was an independent predictor of deteriorated HRQoL 1 year after TAVI (OR 2.24, 95% CI 1.07-4.70, P =?0.003). In frail patients, the absence of peripheral artery disease (OR 0.17, 95% 0.05-0.50, P =?0.001) and renal dysfunction (OR 0.13, 95% CI 0.04-0.41, P =?<0.001) at baseline was associated with improved HRQoL 1 year after TAVI. CONCLUSION:Frailty is associated with deterioration of HRQoL 1 year after TAVI. Notably, HRQoL did improve in frail patients with no peripheral arterial disease or renal impairment at baseline.

SUBMITTER: Goudzwaard JA 

PROVIDER: S-EPMC7583518 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature