Ontology highlight
ABSTRACT:
SUBMITTER: Smidlehner T
PROVIDER: S-EPMC7583847 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Šmidlehner Tamara T Košćak Marta M Božinović Ksenija K Majhen Dragomira D Schmuck Carsten C Piantanida Ivo I
Molecules (Basel, Switzerland) 20200929 19
Two novel isosteric conjugates of guanidiniocarbonyl-pyrrole and 6-bromo-TO (thiazole orange) were prepared, differing only in linker connectivity to cyanine (benzothiazole nitrogen vs. quinoline nitrogen). The quinoline analog was significantly more susceptible to aggregation in an aqueous medium, which resulted in induced circular dichroism (ICD; λ = 450-550 nm) recognition between A-T(U) and G-C basepair containing polynucleotides. The benzothiazole-isostere showed pronounced (four-fold) fluo ...[more]