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Protective Effect of Flavonoids from Ohwia caudata against Influenza a Virus Infection.

ABSTRACT: To identify new potential anti-influenza compounds, we isolated six flavonoids, 2'-hydroxyl yokovanol (1), 2'-hydroxyl neophellamuretin (2), yokovanol (3), swertisin (4), spinosin (5), and 7-methyl-apigenin-6-C-?-glucopyranosyl 2?-O-?-d-xylopyranoside (6) from MeOH extractions of Ohwia caudata. We screened these compounds for antiviral activity using green fluorescent protein (GFP)-expressing H1N1 (A/PR/8/34) influenza A-infected RAW 264.7 cells. Compounds 1 and 3 exhibited significant inhibitory effects against influenza A viral infection in co-treatment conditions. In addition, compounds 1 and 3 reduced viral protein levels, including M1, M2, HA, and neuraminidase (NA), and suppressed neuraminidase (NA) activity in RAW 264.7 cells. These findings demonstrated that 2'-hydroxyl yokovanol and yokovanol, isolated from O. caudate, inhibit influenza A virus by suppressing NA activity. The moderate inhibitory activities of these flavonoids against influenza A virus suggest that they may be developed as novel anti-influenza drugs in the future.

SUBMITTER: Kwon EB 

PROVIDER: S-EPMC7583851 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Protective Effect of Flavonoids from <i>Ohwia caudata</i> against Influenza a Virus Infection.

Kwon Eun Bin EB   Yang Hye Jin HJ   Choi Jang-Gi JG   Li Wei W  

Molecules (Basel, Switzerland) 20200924 19

To identify new potential anti-influenza compounds, we isolated six flavonoids, 2'-hydroxyl yokovanol (<b>1</b>), 2'-hydroxyl neophellamuretin (<b>2</b>), yokovanol (<b>3</b>), swertisin (<b>4</b>), spinosin (<b>5</b>), and 7-methyl-apigenin-6-C-β-glucopyranosyl 2″-<i>O</i>-β-d-xylopyranoside (<b>6</b>) from MeOH extractions of <i>Ohwia caudata</i>. We screened these compounds for antiviral activity using green fluorescent protein (GFP)-expressing H1N1 (A/PR/8/34) influenza A-infected RAW 264.7  ...[more]

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