Racial Differences in Helicobacter pylori CagA Sero-prevalence in a Consortium of Adult Cohorts in the United States.

ABSTRACT:

Background

Prevalence of Helicobacter pylori (H. pylori) infection, the main risk factor for gastric cancer, has been decreasing in the United States; however, there remains a substantial racial disparity. Moreover, the time-trends for prevalence of CagA-positive H. pylori infection, the most virulent form, are unknown in the U.S.

Population

We sought to assess prevalence of CagA-positive H. pylori infection over time by race in the United States.

Methods

We utilized multiplex serology to quantify antibody responses to H. pylori antigens in 4,476 participants across five cohorts that sampled adults from 1985 to 2009. Using log-binomial regression models, we calculated prevalence ratios and 95% confidence intervals for the association

SUBMITTER: Varga MG 

PROVIDER: S-EPMC7584346 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature