Ontology highlight
ABSTRACT:
SUBMITTER: Lomzik M
PROVIDER: S-EPMC7584371 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Łomzik Michał M Hanif Muhammad M Budniok Aleksandra A Błauż Andrzej A Makal Anna A Tchoń Daniel M DM Leśniewska Barbara B Tong Kelvin K H KKH Movassaghi Sanam S Söhnel Tilo T Jamieson Stephen M F SMF Zafar Ayesha A Reynisson Jóhannes J Rychlik Błażej B Hartinger Christian G CG Plażuk Damian D
Inorganic chemistry 20201001 20
Ispinesib is a potent inhibitor of kinesin spindle protein (KSP), which has been identified as a promising target for antimitotic anticancer drugs. Herein, we report the synthesis of half-sandwich complexes of Ru, Os, Rh, and Ir bearing the ispinesib-derived <i>N</i>,<i>N</i>-bidentate ligands (<i>R</i>)- and (<i>S</i>)-2-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one and studies on their chemical and biological properties. Using the enantiomerically pure (<i>R</i>)- and (<i>S</i ...[more]