Structural determinants of dynamic fluctuations between segregation and integration on the human connectome.

ABSTRACT: While segregation and integration of neural information in the neocortex are thought to be important for human behavior and cognition, the neural substrates enabling their dynamic fluctuations remain elusive. To tackle this problem, we aim to identify specific network features of the connectome that are responsible for the emergence of dynamic fluctuations between segregated and integrated patterns in human resting-state functional connectivity. Here we examine the contributions of network features to dynamic fluctuations by constructing rewired surrogate connectome in which network features of interest are selectively preserved, and then by assessing the magnitude of fluctuations simulated with these surrogates. Our analysis demonstrates significant contributions from global geometry and

SUBMITTER: Fukushima M 

PROVIDER: S-EPMC7584581 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature