?-lactolin increases cerebral blood flow in dorsolateral prefrontal cortex in healthy adults: a randomized controlled trial.

ABSTRACT: The number of elderly individuals with age-related cognitive decline or dementia is rapidly increasing. Dairy product consumption, including ?-lactolin, is beneficial for their cognitive function. The underlying mechanism of ?-lactolin's effects on human brain activity is yet to be investigated. We examined the ?-lactolin effects on human cerebral blood flow (CBF) using near-infrared spectroscopy (NIRS) in a placebo-controlled randomized double-blind study, which reported according to the CONSORT guidelines. Fifty healthy participants (aged 45-60 years) were randomly allocated into the ?-lactolin or the placebo group (n = 25 each) and supplemented for 6 weeks. During the 6th week, oxy-hemoglobin during the working memory tasks was measured using 34-channels (CHs) NIRS. The changes of oxy-hemoglobin, which represents the CBF, in CH 23 located at the left dorsolateral prefrontal cortex (DLPFC) during the spatial working memory task showed higher statistical significance (false discovery rate (q) = 0.045) in the ?-lactolin than in the placebo group. The oxy-Hb changes in CH23 have a co-relationship with the working memory task reaction time. This clinical trial showed an increase in the CBF in the left DLPFC area during the 6-week ?-lactolin supplementation. This study contributes to elucidating the underlying mechanisms of ?-lactolin on cognitive performance.

SUBMITTER: Ano Y 

PROVIDER: S-EPMC7585116 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature