Ontology highlight
ABSTRACT:
SUBMITTER: Ertosun MG
PROVIDER: S-EPMC7585165 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ertosun Mustafa Gökhan MG DİlmaÇ Sayra S Hapİl Fatma Zehra FZ TanriÖver Gamze G KÖksoy Sadi S ÖzeŞ Osman Nidai ON
Turkish journal of biology = Turk biyoloji dergisi 20201013 5
E2F1 becomes activated during the G1 phase of the cell cycle, and posttranslational modifications modulate its activity. Activation of G-protein coupled receptors (GPCR) by many ligands induces the activation of adenylate cyclases and the production of cAMP, which activates the PKA enzyme. Activated PKA elicits its biological effect by phosphorylating the target proteins containing serine or threonine amino acids in the RxxS/T motif. Since PKA activation negatively regulates cell proliferation, ...[more]