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Characterization of HIV risks in a Brazilian sickle cell disease population.

ABSTRACT: BACKGROUND:A low prevalence of HIV in sickle cell disease (SCD) patients has been reported in the literature though mechanisms for this are not understood. METHODS:HIV risk behaviors were compared between SCD cases and non-SCD controls using a self-administered audio computer-assisted self-interview. SCD cases were recruited from a multi-center SCD cohort established in Brazil; controls were recruited from SCD social contacts. Categorical variables were analyzed using Chi-Square or Fisher exact test. Continuous variables were compared using the Mann-Whitney U test. RESULTS:There were 152 SCD cases and 154 age/location matched controls enrolled at three participating Brazilian centers during 2016-17. No significant differences in number of sexual partners (lifetime or previous 12?months), male-to-male sex partners or intravenous drug use were observed. Cases received more transfusions, surgeries, and acupuncture treatment. CONCLUSIONS:Besides the risk of transfusion-transmitted HIV, which is now exceedingly rare, SCD and non-SCD participants demonstrated similar HIV risk behaviors. Causes other than risk behaviors such as factors inherent to SCD pathophysiology may explain the reported low prevalence of HIV in SCD.

SUBMITTER: Blatyta PF

PROVIDER: S-EPMC7585195 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Characterization of HIV risks in a Brazilian sickle cell disease population.

Blatyta P F PF Kelly S S Goncalez T T TT Carneiro-Proietti A B AB Salomon T T Miranda C C Sabino E E Preiss L L Maximo C C Loureiro P P Custer B B de Almeida-Neto C C

BMC public health 20201023 1

<h4>Background</h4>A low prevalence of HIV in sickle cell disease (SCD) patients has been reported in the literature though mechanisms for this are not understood.<h4>Methods</h4>HIV risk behaviors were compared between SCD cases and non-SCD controls using a self-administered audio computer-assisted self-interview. SCD cases were recruited from a multi-center SCD cohort established in Brazil; controls were recruited from SCD social contacts. Categorical variables were analyzed using Chi-Square o ...[more]

PMID: 33097032

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Dataset Information

Characterization of HIV risks in a Brazilian sickle cell disease population.

Publications

Characterization of HIV risks in a Brazilian sickle cell disease population.

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