The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.
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ABSTRACT:
SUBMITTER: Pei YF
PROVIDER: S-EPMC7585446 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.
Pei Yu-Fang YF Liu Yao-Zhong YZ Yang Xiao-Lin XL Zhang Hong H Feng Gui-Juan GJ Wei Xin-Tong XT Zhang Lei L
Communications biology 20201023 1
Appendicular lean mass (ALM) is a heritable trait associated with loss of lean muscle mass and strength, or sarcopenia, but its genetic determinants are largely unknown. Here we conducted a genome-wide association study (GWAS) with 450,243 UK Biobank participants to uncover its genetic architecture. A total of 1059 conditionally independent variants from 799 loci were identified at the genome-wide significance level (p < 5 × 10<sup>-9</sup>), all of which were also significant at p < 5 × 10<sup> ...[more]
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