Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC7585592 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Park Jeaneun J Cho Kwang-Hyun KH Lee Hong Joon HJ Choi Jin-Sung JS Rhie Duck-Joo DJ
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20201101 6
Aripiprazole is a quinolinone derivative approved as an atypical antipsychotic drug for the treatment of schizophrenia and bipolar disorder. It acts as with partial agonist activities at the dopamine D2 receptors. Although it is known to be relatively safe for patients with cardiac ailments, less is known about the effect of aripiprazole on voltage-gated ion channels such as transient A-type K<sup>+</sup> channels, which are important for the repolarization of cardiac and neuronal action potenti ...[more]