Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis.

ABSTRACT:

Objective

Transformation of white into brown fat ("browning") reduces obesity in many preclinical models and holds great promise as a therapeutic concept in metabolic disease. Vitamin A metabolites (retinoids) have been linked to thermogenic programming of adipose tissue; however, the physiologic importance of systemic retinoid transport for adipose tissue browning and adaptive thermogenesis is unknown.

Methods

We performed cold exposure studies in mice and humans and used a genetic model of defective vitamin A transport, the retinol binding protein deficient (Rbp^-/-) mouse, to study the effects of cooling on systemic vitamin A and the relevance of intact retinoid transport on cold-induced adipose tissue browning.

Results

We show that cold stimulation in mi

SUBMITTER: Fenzl A 

PROVIDER: S-EPMC7585949 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature