Ontology highlight
ABSTRACT:
SUBMITTER: Wojcik M
PROVIDER: S-EPMC7586933 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Wójcik Magdalena M Szala Kamil K van Merkerk Ronald R Quax Wim J WJ Boersma Ykelien L YL
Proteins 20200621 11
Sortases are a group of enzymes displayed on the cell-wall of Gram-positive bacteria. They are responsible for the attachment of virulence factors onto the peptidoglycan in a transpeptidation reaction through recognition of a pentapeptide substrate. Most housekeeping sortases recognize one specific pentapeptide motif; however, Streptococcus pyogenes sortase A (SpSrtA WT) recognizes LPETG, LPETA and LPKLG motifs. Here, we examined SpSrtA's flexible substrate specificity by investigating the role ...[more]