Dataset Information

Airway bacterial carriage and childhood respiratory health: A population-based prospective cohort study.

ABSTRACT:

Background

Airway bacterial carriage might play a role in respiratory disease. We hypothesize that nasal carriage with Staphylococcus aureus or nasopharyngeal carriage with Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae predisposes individuals to adverse respiratory health.

Objective

To examine the association of early-life airway bacterial carriage with respiratory tract infections and vice versa, and of early-life airway bacterial carriage with wheezing, lung function, and asthma in later childhood.

Methods

We collected upper airway swabs for bacterial culturing for S aureus, H influenzae, M catarrhalis, and H influenzae at six timepoints between the ages of 6 weeks and 6 years among 945 children participating in a population-based prospective cohort study. Information on respiratory tract infections and wheezing until age 6 years, and asthma at age 10 years was obtained by questionnaires. Lung function at age 10 years was measured by spirometry. We tested possible bidirectional associations between airway bacterial carriage and respiratory tract infections by cross-lagged models, and associations of repeatedly measured airway bacterial carriage with wheezing, lung function, and asthma by generalized estimating equations models and regression models.

Results

Cross-lagged modeling showed that early-life airway bacterial carriage was not consistently associated with upper and lower respiratory tract infections or vice versa. Nasopharyngeal carriage with any bacteria in infancy was associated with an increased risk of wheezing (OR [95% CI]: 1.66 [1.31, 2.10]). Airway bacterial carriage was not consistently associated with school-age lung function or asthma.

Conclusion

Nasopharyngeal carriage with any bacteria is associated with wheezing, but not respiratory tract infections, asthma, or lung function.

SUBMITTER: van Meel ER

PROVIDER: S-EPMC7587008 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Airway bacterial carriage and childhood respiratory health: A population-based prospective cohort study.

van Meel Evelien R ER Jaddoe Vincent W V VWV Looman Kirsten I M KIM de Jongste Johan C JC Moll Henriëtte A HA Duijts Liesbeth L

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20200630 7

<h4>Background</h4>Airway bacterial carriage might play a role in respiratory disease. We hypothesize that nasal carriage with Staphylococcus aureus or nasopharyngeal carriage with Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae predisposes individuals to adverse respiratory health.<h4>Objective</h4>To examine the association of early-life airway bacterial carriage with respiratory tract infections and vice versa, and of early-life airway bacterial carriage with wheez ...[more]

PMID: 32524657

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Dataset Information

Airway bacterial carriage and childhood respiratory health: A population-based prospective cohort study.

Background

Objective

Methods

Results

Conclusion

Publications

Airway bacterial carriage and childhood respiratory health: A population-based prospective cohort study.

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