Ontology highlight
ABSTRACT:
SUBMITTER: Vue TY
PROVIDER: S-EPMC7587013 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Vue Tou Yia TY Kollipara Rahul K RK Borromeo Mark D MD Smith Tyler T Mashimo Tomoyuki T Burns Dennis K DK Bachoo Robert M RM Johnson Jane E JE
Glia 20200623 12
Glioblastomas (GBMs) are incurable brain tumors with a high degree of cellular heterogeneity and genetic mutations. Transcription factors that normally regulate neural progenitors and glial development are aberrantly coexpressed in GBM, conferring cancer stem-like properties to drive tumor progression and therapeutic resistance. However, the functional role of individual transcription factors in GBMs in vivo remains elusive. Here, we demonstrate that the basic-helix-loop-helix transcription fact ...[more]