In Silico Molecular Study of Tryptophan Bitterness.
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ABSTRACT:
SUBMITTER: Di Pizio A
PROVIDER: S-EPMC7587216 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
In Silico Molecular Study of Tryptophan Bitterness.
Di Pizio Antonella A Nicoli Alessandro A
Molecules (Basel, Switzerland) 20201011 20
Tryptophan is an essential amino acid, required for the production of serotonin. It is the most bitter amino acid and its bitterness was found to be mediated by the bitter taste receptor TAS2R4. Di-tryptophan has a different selectivity profile and was found to activate three bitter taste receptors, whereas tri-tryptophan activated five TAS2Rs. In this work, the selectivity/promiscuity profiles of the mono-to-tri-tryptophans were explored using molecular modeling simulations to provide new insig ...[more]
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