Ontology highlight
ABSTRACT:
SUBMITTER: Cai J
PROVIDER: S-EPMC7587333 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cai Jianghong J Hosmane Narayan S NS Takagaki Masao M Zhu Yinghuai Y
Molecules (Basel, Switzerland) 20201014 20
In comparison with pristine sinomenine and carborane precursors, the calculations of molecular docking with matrix metalloproteinases (MMPs) and methylcarboranyl-<i>n</i>-butyl sinomenine showed improved interactions. Accordingly, methylcarboranyl-<i>n</i>-butyl sinomenine shows a high potential in the treatment of rheumatoid arthritis (RA) in the presence of slow neutrons. The reaction of potassium salt of sinomenie, which is generated from the deprotonation of sinomenine (<b>1</b>) using potas ...[more]