Ontology highlight
ABSTRACT:
SUBMITTER: Hafeez U
PROVIDER: S-EPMC7587605 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Hafeez Umbreen U Parakh Sagun S Gan Hui K HK Scott Andrew M AM
Molecules (Basel, Switzerland) 20201016 20
Antibody-drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent cytotoxic payload. ADCs provide a unique opportunity to deliver drugs to tumor cells while minimizing toxicity to normal tissue, achieving wider therapeutic windows and enhanced pharmacokinetic/pharmacodynamic properties. To date, nine ADCs have been approved by the FDA and more than 80 ADCs are under clinical ...[more]