Effects of Integrase Inhibitor-Based ART on the NLRP3 Inflammasome Among ART-Naive People With HIV.
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ABSTRACT:
SUBMITTER: Toribio M
PROVIDER: S-EPMC7588107 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Effects of Integrase Inhibitor-Based ART on the NLRP3 Inflammasome Among ART-Naïve People With HIV.
Toribio Mabel M Burdo Tricia H TH Fulda Evelynne S ES Cetlin Madeline M Chu Sarah M SM Feldpausch Meghan N MN Robbins Gregory K GK Neilan Tomas G TG Melbourne Kathleen K Grinspoon Steven K SK Zanni Markella V MV
Open forum infectious diseases 20200929 10
The NOD-like receptor protein family pyrin domain containing 3 (NLRP3) inflammasome, activated in the setting of HIV, contributes to pro-atherogenic inflammation. Among antriretroviral therapy-naïve people with HIV (vs controls), levels of caspase-1-a key component of the NLRP3 inflammasome-were significantly increased. Six months of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate significantly decreased caspase-1 levels in association with CD4+/CD8+ ratio recovery.<b>Trial r ...[more]
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2021-12-09 | GSE157198 | GEO
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