Ontology highlight
ABSTRACT:
SUBMITTER: Bassil F
PROVIDER: S-EPMC7588140 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Bassil Fares F Meymand Emily S ES Brown Hannah J HJ Xu Hong H Cox Timothy O TO Pattabhiraman Shankar S Maghames Chantal M CM Wu Qihui Q Zhang Bin B Trojanowski John Q JQ Lee Virginia M-Y VM
The Journal of experimental medicine 20210101 1
α-Synuclein (α-syn) and tau aggregates are the neuropathological hallmarks of Parkinson's disease (PD) and Alzheimer's disease (AD), respectively, although both pathologies co-occur in patients with these diseases, suggesting possible crosstalk between them. To elucidate the interactions of pathological α-syn and tau, we sought to model these interactions. We show that increased accumulation of tau aggregates occur following simultaneous introduction of α-syn mousepreformed fibrils (mpffs) and A ...[more]