GSK-3? activation is required for ZIP-induced disruption of learned fear.
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ABSTRACT:
SUBMITTER: Song S
PROVIDER: S-EPMC7588416 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
GSK-3β activation is required for ZIP-induced disruption of learned fear.
Song Sukwoon S Kim Jihye J Park Kyungjoon K Lee Junghwa J Park Sewon S Lee Sukwon S Kim Jeongyeon J Hong Ingie I Song Beomjong B Choi Sukwoo S
Scientific reports 20201026 1
The myristoylated zeta inhibitory peptide (ZIP), which was originally developed as a protein kinase C/Mζ (PKCζ/PKMζ) inhibitor, is known to produce the loss of different forms of memories. However, ZIP induces memory loss even in the absence of PKMζ, and its mechanism of action, therefore, remains elusive. Here, through a kinome-wide screen, we found that glycogen synthase kinase 3 beta (GSK-3β) was robustly activated by ZIP in vitro. ZIP induced depotentiation (a cellular substrate of memory er ...[more]
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