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Multi-gene signature of microcalcification and risk prediction among Taiwanese breast cancer.


ABSTRACT: Microcalcification is one of the most common radiological and pathological features of breast ductal carcinoma in situ (DCIS), and to a lesser extent, invasive ductal carcinoma. We evaluated messenger RNA (mRNA) transcriptional profiles associated with ectopic mammary mineralization. A total of 109 breast cancers were assayed with oligonucleotide microarrays. The associations of mRNA abundance with microcalcifications and relevant clinical features were evaluated. Microcalcifications were present in 86 (79%) patients by pathological examination, and 81 (94%) were with coexistent DCIS, while only 13 (57%) of 23 patients without microcalcification, the invasive diseases were accompanied with DCIS (?2-test, P?

SUBMITTER: Tsai HT 

PROVIDER: S-EPMC7588423 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Multi-gene signature of microcalcification and risk prediction among Taiwanese breast cancer.

Tsai Hsin-Tien HT   Huang Ching-Shui CS   Tu Chao-Chiang CC   Liu Chih-Yi CY   Huang Chi-Jung CJ   Ho Yuan-Soon YS   Tu Shih-Hsin SH   Tseng Ling-Ming LM   Huang Chi-Cheng CC  

Scientific reports 20201026 1


Microcalcification is one of the most common radiological and pathological features of breast ductal carcinoma in situ (DCIS), and to a lesser extent, invasive ductal carcinoma. We evaluated messenger RNA (mRNA) transcriptional profiles associated with ectopic mammary mineralization. A total of 109 breast cancers were assayed with oligonucleotide microarrays. The associations of mRNA abundance with microcalcifications and relevant clinical features were evaluated. Microcalcifications were presen  ...[more]

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