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Qualitative and quantitative differences in endometrial inflammatory gene expression precede the development of bovine uterine disease.


ABSTRACT: The transcriptome of the endometrium early postpartum was profiled to determine if inflammatory gene expression was elevated in cows which subsequently developed uterine disease. Endometrial cytobrush samples were collected at 7 days postpartum (DPP) from 112 Holstein-Friesian dairy cows, from which 27 were retrospectively chosen for RNA-seq on the basis of disease classification [ten healthy and an additional 17 diagnosed with cytological endometritis (CYTO), or purulent vaginal discharge (PVD)] at 21 DPP. 297 genes were significantly differentially expressed between cows that remained healthy versus those that subsequently developed PVD, including IL1A and IL1B (adjusted p?

SUBMITTER: Brewer A 

PROVIDER: S-EPMC7588428 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Qualitative and quantitative differences in endometrial inflammatory gene expression precede the development of bovine uterine disease.

Brewer Amy A   Cormican Paul P   Lim Joseph J JJ   Chapwanya Aspinas A   O'Farrelly Cliona C   Meade Kieran G KG  

Scientific reports 20201026 1


The transcriptome of the endometrium early postpartum was profiled to determine if inflammatory gene expression was elevated in cows which subsequently developed uterine disease. Endometrial cytobrush samples were collected at 7 days postpartum (DPP) from 112 Holstein-Friesian dairy cows, from which 27 were retrospectively chosen for RNA-seq on the basis of disease classification [ten healthy and an additional 17 diagnosed with cytological endometritis (CYTO), or purulent vaginal discharge (PVD)  ...[more]

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