Ontology highlight
ABSTRACT:
SUBMITTER: Kefala Stavridi A
PROVIDER: S-EPMC7588668 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Kefala Stavridi Antonia A Appleby Robert R Liang Shikang S Blundell Tom L TL Chaplin Amanda K AK
Essays in biochemistry 20201001 5
Non-homologous end joining (NHEJ) is one of the two principal damage repair pathways for DNA double-strand breaks in cells. In this review, we give a brief overview of the system including a discussion of the effects of deregulation of NHEJ components in carcinogenesis and resistance to cancer therapy. We then discuss the relevance of targeting NHEJ components pharmacologically as a potential cancer therapy and review previous approaches to orthosteric regulation of NHEJ factors. Given the limit ...[more]