Ontology highlight
ABSTRACT:
SUBMITTER: Althurwi SI
PROVIDER: S-EPMC7589098 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Althurwi Safiah Ibrahim SI Yu Jun Q JQ Beale Philip P Huq Fazlul F
International journal of molecular sciences 20201012 20
In the present study, cisplatin, artemisinin, and oleanolic acid were evaluated alone, and in combination, on human ovarian A2780, A2780<sup>ZD0473R</sup>, and A2780<sup>cisR</sup> cancer cell lines, with the aim of overcoming cisplatin resistance and side effects. Cytotoxicity was assessed by MTT reduction assay. Combination index (CI) values were used as a measure of combined drug effect. MALDI TOF/TOF MS/MS and 2-DE gel electrophoresis were used to identify protein biomarkers in ovarian cance ...[more]