Ontology highlight
ABSTRACT:
SUBMITTER: Stan TL
PROVIDER: S-EPMC7589489 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Stan Tiberiu Loredan TL Soylu-Kucharz Rana R Burleigh Stephen S Prykhodko Olena O Cao Ling L Franke Naomi N Sjögren Marie M Haikal Caroline C Hållenius Frida F Björkqvist Maria M
Scientific reports 20201026 1
Huntington's disease (HD) is a progressive, multifaceted neurodegenerative disease associated with weight loss and gut problems. Under healthy conditions, tight junction (TJ) proteins maintain the intestinal barrier integrity preventing bacterial translocation from the intestinal lumen to the systemic circulation. Reduction of TJs expression in Parkinson's disease patients has been linked with increased intestinal permeability-leaky gut syndrome. The intestine contains microbiota, most dominant ...[more]