Ontology highlight
ABSTRACT:
SUBMITTER: Drake LR
PROVIDER: S-EPMC7589526 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Drake Lindsey R LR Brooks Allen F AF Mufarreh Anthony J AJ Pham Jonathan M JM Koeppe Robert A RA Shao Xia X Scott Peter J H PJH Kilbourn Michael R MR
ACS chemical neuroscience 20180817 12
Visualizing the in vivo activity of monoamine oxidase B (MAO-B) is a valuable tool in the ongoing investigation of astrogliosis in neurodegeneration. Existing strategies for imaging changes in MAO enzyme expression or activity have utilized the irreversible suicide inhibitors or high-affinity reversibly binding inhibitors as positron emission tomography (PET) ligands. As an alternative approach, we developed 4-methyl-7-[(1-[<sup>11</sup>C]methyl-1,2,3,6-tetrahydropyridin-4-yl)oxy]-2 H-chromen-2- ...[more]