Therapy Resistance, Cancer Stem Cells and ECM in Cancer: The Matrix Reloaded.
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ABSTRACT:
SUBMITTER: Kesh K
PROVIDER: S-EPMC7589733 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Therapy Resistance, Cancer Stem Cells and ECM in Cancer: The Matrix Reloaded.
Kesh Kousik K Gupta Vineet K VK Durden Brittany B Garrido Vanessa V Mateo-Victoriano Beatriz B Lavania Shweta P SP Banerjee Sulagna S
Cancers 20201021 10
The extracellular matrix (ECM) has remained an enigmatic component of the tumor microenvironment. It drives metastasis via its interaction with the integrin signaling pathway, contributes to tumor progression and confers therapy resistance by providing a physical barrier around the tumor. The complexity of the ECM lies in its heterogeneous composition and complex glycosylation that can provide a support matrix as well as trigger oncogenic signaling pathways by interacting with the tumor cells. I ...[more]
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