Ontology highlight
ABSTRACT:
SUBMITTER: Baek JY
PROVIDER: S-EPMC7589869 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Baek Ji-Ye JY Yun Hye-Hyeon HH Jung Soon-Young SY Lee Jeehan J Yoo Kyunghyun K Lee Jeong-Hwa JH
Cells 20201019 10
BCL-2 interacting cell death suppressor (BIS), also known as BAG3, is a multifunctional protein. Aberrant expression and mutation of BIS have been implicated in cancers and myopathy. However, there have only been a few studies on the splicing of BIS pre-mRNA. In the present study, through RT-PCR and sequencing in various cell lines and mouse tissues, we identified for the first time the presence of BIS mRNA isomers in which exon 3 or exons 2-3 are skipped. We also demonstrated that the depletion ...[more]