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Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma.


ABSTRACT: Most gliomas are associated with a fatal prognosis and remain incurable because of their infiltrative growth. Consequently, the addition of immunotherapy to conventional therapy may improve patient outcomes. Here, we analyzed T-cell infiltration and, therefore, a major prerequisite for successful immunotherapy in a series of primary (n = 78) and recurrent (n = 66) isocitrate dehydrogenase (IDH)-mutant glioma and their changes following treatment with radio- and/or chemotherapy. After multicolor immunofluorescence staining, T cells were counted in entire tumor sections using a software-based setup. Newly diagnosed diffuse IDH-mutant gliomas displayed a median T-cell infiltration of 0.99 T cells/mm2 (range: 0-48.97 CD3+ T cells/mm2), which was about two-fold increased for CD3+, helper, and cytotoxic T cells in recurrent glioma. Furthermore, T-cell infiltration of recurrent tumors was associated with the type of adjuvant treatment of the primary tumor. Interestingly, only glioma patients solely receiving radiotherapy presented consistently with increased T-cell infiltration in their recurrent tumors. This was confirmed in a subset of 27 matched pairs. In conclusion, differences in the T-cell infiltration of primary and recurrent gliomas were demonstrated, and evidence was provided for a beneficial long-term effect on T-cell infiltration upon treatment with radiotherapy.

SUBMITTER: Makarevic A 

PROVIDER: S-EPMC7590222 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma.

Makarevic Anastasia A   Rapp Carmen C   Dettling Steffen S   Reuss David D   Jungk Christine C   Abdollahi Amir A   von Deimling Andreas A   Unterberg Andreas A   Herold-Mende Christel C   Warta Rolf R  

International journal of molecular sciences 20201021 20


Most gliomas are associated with a fatal prognosis and remain incurable because of their infiltrative growth. Consequently, the addition of immunotherapy to conventional therapy may improve patient outcomes. Here, we analyzed T-cell infiltration and, therefore, a major prerequisite for successful immunotherapy in a series of primary (<i>n</i> = 78) and recurrent (<i>n</i> = 66) isocitrate dehydrogenase (IDH)-mutant glioma and their changes following treatment with radio- and/or chemotherapy. Aft  ...[more]

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