Ontology highlight
ABSTRACT:
SUBMITTER: Makarevic A
PROVIDER: S-EPMC7590222 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Makarevic Anastasia A Rapp Carmen C Dettling Steffen S Reuss David D Jungk Christine C Abdollahi Amir A von Deimling Andreas A Unterberg Andreas A Herold-Mende Christel C Warta Rolf R
International journal of molecular sciences 20201021 20
Most gliomas are associated with a fatal prognosis and remain incurable because of their infiltrative growth. Consequently, the addition of immunotherapy to conventional therapy may improve patient outcomes. Here, we analyzed T-cell infiltration and, therefore, a major prerequisite for successful immunotherapy in a series of primary (<i>n</i> = 78) and recurrent (<i>n</i> = 66) isocitrate dehydrogenase (IDH)-mutant glioma and their changes following treatment with radio- and/or chemotherapy. Aft ...[more]